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G.N.
Balerio, E. Aso, R. Maldonado. Role
of the cannabinoid system in the effects induced by nicotine
on anxiety-like behaviour in mice. Psychopharmacology,
184: 504513 (2006).
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Brea, M. Castro, M. I. Loza, C. F. Masaguer, E. Raviña,
C. Dezi, M. Pastor, F. Sanz, A. Cabrero-Castel, B. Galán-Rodríguez,
E. Fernández-Espejo, R. Maldonado, P. Robledo. QF2004B,
a potential antipsychotic butyrophenone derivative with
similar pharmacological properties to clozapine. Neuropharmacology,
51:251-62 (2006).
A.
Castañé, E. Célérier, M. Martín,
C. Ledent, M. Parmentier, R. Maldonado, O. Valverde. Development
and expresion of neuropathic pain in CB1 knockout mice.
Neuropharmacology, 50: 111-122 (2006).
A.
Castañé, G. Soria, C. Ledent, R. Maldonado,
O. Valverde. Attenuation
of nicotine-induced rewarding effects in A2A knockout mice.
Neuropharmacology, 51:631-40 (2006).
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Célérier, T. Ahdepil, H. Wikander, F. Berrendero,
F. Nyberg, R. Maldonado. Influence
of the anabolic-androgenic steroid nandrolone on cannabinoid
dependence. Neuropharmacology, 50(7):788-806 (2006).
M.
Dierssen, M. Gratacòs, I. Sahún, M. Martín,
X. Gallego, A. Amador-Arjona, M. Martínez de Lagrán,
P. Murtra, E. Martí, M. A. Pujana, I. Ferrer, E.
Dalfó, C. Martínez-Cué, J. Flórez,
J. F. Torres-Peraza, J. Alberch, R. Maldonado, C. Fillat,
X. Estivill. Transgenic
mice overexpressing the full-length neurotrophin receptor
TrkC exhibit increased catecholaminergic neuron density
in specific brain areas and increased anxiety-like behavior
and panic reaction. Neurobiology of disease, In Press.
L.
Galeote, B.L. Kieffer, R. Maldonado, F. Berrendero. Mu-opioid
receptors are involved in the tolerance to nicotine antinociception.
Journal of Neurochemistry, 97: 416423 (2006).
R.
Maldonado, O. Valverde, F. Berrendero. The
involvement of the endocannabinoid system in drug addiction.
Trends in Neuroscience, Invited review. 29:225-32 (2006).
V.
Mendizábal, A. Zimmer, R. Maldonado. Involvement
of k/Dynorphin System in WIN 55,212-2 Self-Administration
in Mice. Neuropsychopharmacology, 31: 1957-66 (2006).
X.
Nadal, Josep-Eladi Baños, B. L. Kieffer, R. Maldonado.
Neuropathic pain is enhanced in d-opioid receptor knockout
mice. European Journal of Neuroscience, 23: 830834
(2006). Nadal et al_2006.pdf
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Pol, P. Murtra, L. Caracuel, O. Valverde, M.M. Puig, R.
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of opioid receptors and c-fos in CB1 knockout mice exposed
to neuropathic pain. Neuropharmacology, 50: 123-132
(2006).
G.
Soria, A. Castañé, C. Ledent, M. Parmentier,
R. Maldonado, O. Valverde. The
lack of A2A adenosine receptors diminishes the reinforcing
efficacy of cocaine. Neuropsychopharmacology, 31:978-987
(2006). Soria et al 2006.pdf
J.M.
Trigo, F. Panayi, G. Soria, R. Maldonado, P. Robledo. A
reliable model of intravenous MDMA self-administration in
naïve mice. Psychopharmacology, 184: 212220,
(2006).
G.N.
Balerio, E. Aso, R. Maldonado. Involvement
of the opioid system in the effects induced by nicotine
in anxiety-like behaviour in mice. Psychopharmacology,
181: 260-269 (2005).
F.Berrendero,
V. Mendizábal, P. Robledo, L. Galeote, A. Bilkei-Gorzo,
A. Zimmer, R. Maldonado. Nicotine-induced
antinociception, rewarding effects and physical dependence
are mediated by preproenkephalin derivates. Journal
of Neuroscience, 25: 1103-1112 (2005).
A.
Castañé, F. Berrendero, R. Maldonado. The
role of the cannabinoid system in nicotine addiction.
Pharmacology Biochemistry and Behavior, 81: 381-386 (2005).
P.
Laurent, J.A. Becker, O. Valverde, C. Ledent, A. De , J.A.
Becker, O. Valverde, C. Ledent, A. De Kerchove dExaerde,
S.N. Schiffmann, R. Maldonado, G. Vassart, M. Parmentier.
The prolactin-releasing
peptide antagonizes the opioid system through its receptor
GPR10. Nature Neuroscience, 8: 1735-1741 (2005).
G.
Soria, V. Mendizábal, C. Touriño, P. Robledo,
C. Ledent, M. Parmentier, R. Maldonado, O. Valverde. Lack
of CB1 receptor impairs cocaine self-administration.
Neuropsychopharmacology, 30: 1670-1680 (2005).
L.
Urigüen, F. Berrendero, C. Ledent, R. Maldonado, J.
Manzanares. k- and
d-opioid receptor functional activities are increased in
the caudate putamen of cannabinoid CB1 receptor knockout
mice. European Journal of Neuroscience, 22: 21062110
(2005).
G.N.
Balerio, E. Aso, F. Berrendero, P. Murtra, R. Maldonado.
Delta9-tetrahydrocannabinol
decreases somatic and motivational manifestations of nicotine
withdrawal in mice. European Journal of Neuroscience,
20: 2737-2748 (2004).
- A. Castañé, R. Maldonado, O. Valverde. Role
of different brain structures in the behavioural expression
of WIN 55,212-2 withdrawal in mice. British Journal of Pharmacology,
142: 1309-1317 (2004).
E.
Célérier, G. Simonnet, R. Maldonado. Prevention
of fentanyl-induced delayed pronociceptive effects in mice
lacking the protein kinase Cgamma gene. Neuropharmacology,
46: 264-272 (2004).
J.A.
García-Sevilla, M. Ferrer-Alcón, M. Martín,
B.L. Kieffer, R. Maldonado. Neurofilament
proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid
receptor gene knockout mice: effects of chronic morphine
administration.
Neuropharmacology, 46: 519-530 (2004).
- P. Robledo, G. Balerio, F. Barrendero, R. Maldonado. Study
of the behavioral responses related to the potential addictive
properties of MDMA in mice. Naunyn-Schmiedebergs Archives
of Pharmacology, 369: 338-349 (2004).
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Robledo, V. Mendizabal, J. Ortuño, R. de la Torre,
B.L. Kieffer, R. Maldonado. The
rewarding properties of MDMA are preserved in mice lacking
mu-opioid receptors. European Journal of Neuroscience,
20: 853-858 (2004).
G.
Soria, A. Castañé, F. Berrendero, C. Ledent,
M. Parmentier, R. Maldonado, O. Valverde. Adenosine
A2A receptors are involved in physical dependence and place
conditioning induced by THC. European Journal of Neuroscience,
20: 2203-2213 (2004).
O.
Valverde, T. Mantamadiotis, M. Torrecilla, L. Ugedo, J.
Pineda, S. Bleckmann, P. Gass, O. Kretz, J.M. Mitchell,
G. Schütz, R. Maldonado. Modulation
of anxiety-like behavior and morphine dependence in CREB-deficient
mice. Neuropsychopharmacology, 29: 1122-1133 (2004).
- O. Valverde, P. Robledo, R. Maldonado. Involvement of
the endogenous opioid system in cannabinoid responses. Current
Medicinal Chemistry-CNS Agents, 4: 183-193 (2004).
F.
Berrendero, A. Castañé, C. Ledent, M. Parmentier,
R. Maldonado, O. Valverde. Increase
of morphine withdrawal in mice lacking A2a receptors and
no changes in CB1/A2a double knockout mice. European
Journal of Neuroscience, 17: 315-324 (2003).
F.
Berrendero, V. Mendizábal, P. Murtra, B.L. Kieffer,
R. Maldonado. Cannabinoid
receptor and WIN 55 212-2-stimulated ([35S]-GTP?S binding
in the brain of mu-, delta- and kappa-opioid receptor knockout
mice. European Journal of Neuroscience, 18: 2197-2202
(2003).
A.
Castañé, P. Robledo, A. Matifas, B.L. Kieffer,
R. Maldonado. Cannabinoid
withdrawal syndrome is reduced in double mu and delta opioid
receptor knockout mice. European Journal of Neuroscience,
17: 155- 159 (2003).
- E. Célérier, F.M. Yadzi, A. Castañé,
S. Ghozland, F. Nyberg, R. Maldonado. Effects of nandrolone
on acute morphine responses, tolerance and dependence in
mice. European Journal of Pharmacology, 465: 69-81 (2003).
- S. Le Guen, M. Mas Nieto, C. Canestrelli, H. Chen, M.C.
Fournié-Zaluski, A. Cupo, R. Maldonado, B.P. Roques,
F. Noble. Pain management by a new series of dual inhibitors
of enkephalin degrading enzymes: long lasting antinociceptive
properties and potentiation by CCK2 antagonist or methadone.
Pain, 104: 139-148 (2003).
- R. Maldonado. The neurobiology of addiction. Journal of
Neural Transmission, 66: 1-14 (2003).
- R. Maldonado, O. Valverde. Participation of the opioid
system in cannabinoid-induced antinociception and emotional-like
responses. European Neuropsychopharmacology, 13: 401-410
(2003).
- M. Martín, A. Matifas, R. Maldonado, B.L. Kieffer.
Acute antinoceptive responses in single and combinatorial
opioid receptor knockout mice: distinct mu, delta and kappa
tones. European Journal of Neuroscience, 17: 701-708 (2003).
- M. Martín, C. Otto, M.T. Santamarta, M. Torrecilla,
J. Pineda, G. Schütz, R. Maldonado. Morphine withdrawal
is modified in pituitary adenylate cyclase-activating polipeptide
type I-receptor-deficient mice. Molecular Brain Research,
110: 109-118 (2003).
F.
Berrendero, B.L. Kieffer, R. Maldonado. Attenuation
of nicotine-induced antinociception, rewarding effects,
and dependence in mu-opioid receptor knock-out mice.
Journal of Neuroscience, 22: 10935-10940 (2002).
- F. Berrendero, R. Maldonado. Involvement of the opioid
system in the anxiolytic-like effects induced by Delta(9)-tetrahydrocannabinol.
Psychopharmacology, 163: 111-117 (2002).
A.
Castañé, E. Valjent, C. Ledent, M. Parmentier,
R. Maldonado, O. Valverde. Lack
of CB1 cannabinoid receptors modifies nicotine behavioural
responses, but not nicotine abstinence. Neuropharmacology,
43: 857-867 (2002).
- S. Ghozland, F. Aguado, J.F. Espinosa-Parrilla, E. Soriano,
R. Maldonado. Spontaneous network activity of cerebellar
granule neurons: impairment by in vivo chronic cannabinoid
administration. European Journal of Neuroscience, 16: 641-651
(2002).
S.
Ghozland, H.W.D. Matthews, F. Simonin, D. Filliol, B.L.
Kieffer, R. Maldonado. Motivocional
effects of cannabinoids are mediated by mu-opioid and kappa-opioid
receptors. Journal of Neuroscience, 22: 1146-1154 (2002).
- M. Maccarrone, O. Valverde, M.L. Barbaccia, A. Castañé,
R. Maldonado, C. Ledent, M. Parmentier, A. Finazzi-Agro.
Age-related changes of anandamide metabolism in CB1 cannabinoid
receptor knockout mice: correlation with behaviour. European
Journal of Neuroscience, 15: 1178-1186 (2002).
- R. Maldonado. Study of cannabinoid dependence in animals.
Pharmacology & Therapeutics, 95: 153-164 (2002).
R.
Maldonado, F. Rodríguez de Fonseca. Cannabinoid
addiction: behavioral models and neural correlates.
Journal of Neuroscience, 22: 3326-3331 (2002).
- M. Martin, C. Ledent, M. Parmentier, R. Maldonado, O.
Valverde. Involvement of CB-1 cannabinoid receptors in emotional
behaviour. Psycochopharmacology, 159: 379-387 (2002).
C.
Mazzucchelli, C. Vantaggiato, A. Ciamei, S. Fasano, P. Pakhotin,
W. Krezel, H. Welzl, D.P. Wolfer, G. Pages, O. Valverde,
A. Marowsky, A. Porrazzo, P.C. Orban, R. Maldonado, M.U.
Ehrengruber, V. Cestari, H.P. Lipp, P.F. Chapman, J. Pouysségur,
R. Brambilla. Knockout
of ERK1 MAP kinase enhances synaptic plasticity in the striatum
and facilitates striatal-mediated learning and memory.
Neuron, 34: 807-820 (2002).
- E. Valjent, J. Mitchell, M.J. Besson, J. Caboche, R. Maldonado.
Behavioural and biochemical interactions between ?9-tetrahidrocannabinol
and nicotine. British Journal of Pharmacology, 135: 564-578
(2002).
- D. Hutcheson, H.W.D. Matthes, E. Valjent, P. Sanchez-Blazquez,
M. Rodriguez-Diaz, J. Garzon, B.L. Kieffer, R. Maldonado.
Lack of dependence and rewarding effects of deltorphin II
in mu-opioid receptor-deficient mice. European Journal of
Neuroscience, 13: 153-161 (2001).
- R. Maldonado, C. Severini, H.W.D. Matthes, B.L. Kieffer,
P. Melchiorri, L. Negri
Activity of mu- and delta-opioid agonists in vas deferens
from mice deficient in MOR gene. British Journal of Pharmacology,
132: 1485-1492 (2001).
M.
Navarro, M.R.A. Carrera, W. Fratta, O. Valverde, G. Cossu,
L. Fattore, J.A. Chowen, R. Gómez, I. del Arco, M.A.
Villanúa, R. Maldonado, G.F. Koob, F. Rodríguez
de Fonseca. Functional
Interaction between opioid and cannabinoid receptors in
drug self-administration. Journal of Neuroscience, 21:
5344-5350 (2001).
C.
Otto, Y. Kovalchuk, D. Wolfer, P. Gass. M. Martin, W. Zuschratter,
H.J. Gröne, C. Kellendonk, F. Tronche, R. Maldonado,
H. P. Lipp, A. Konnerth, G. Schütz. Impairment
of mossy fiber long-term potentiation and associative learning
in pituitary adenylate cyclase activating polypeptide type
I receptor-deficient mice. Journal of Neuroscience,
21: 5520-5527 (2001).
- C. Otto, M. Martin, D. P. Wolfer, H. P. Lipp, R. Maldonado,
G. Schütz. Altered emotional behaviour in PACAP-type-I-receptor-deficient
mice. Molecular Brain Research, 92: 78-84 (2001).
- E. Valjent, C. Pages, M. Rogard, M. J. Besson , R. Maldonado,
J. Caboche. Delta-9-tetrahydrocannabinolinduced MAPK-/ERK
and Elk-1 activation in vivo depends on dopaminergic transmission.
European Journal of Neuroscience, 14: 342-352 (2001).
A.
Zimmer, E. Valjent, M. König, A. M. Zimmer, P. Robledo,
H. Hahn, O. Valverde, R. Maldonado. Absense
of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient
mice. Journal of Neuroscience, 21: 9499-9505 (2001).
- D. Filliol, S. Ghozland, J. Chluba, M. Martin, H.W.D.
Matthes, F. Simonin, K. Befort, C. Gavériaux-Ruff,
A. Dierich, M. LeMeur, O. Valverde, R. Maldonado, B.L. Kieffer.
Mice deficient for delta- and mu-opiod receptors exhibit
opposing alterations of emotional responses. Nature Genetics,
25: 195-200 (2000).
- D. Hutcheson, F. Subhan, D.M. Pache, R. Maldonado, M.C.
Fournié-Zaluski, B.P. Roques, R.D.E. Sewell. Analgesic
doses of the enkephalin degrading enzyme inhibitor RB 120
do not have discriminative stimulus properties. European
Journal of Pharmacology, 401: 197-204 (2000).
- M. Martin, C. Ledent, M. Parmentier, R. Maldonado, O.
Valverde. Cocaine, but not morphine, induces conditioned
place preference and sensitization to locomotor responses
in CB1 knockout mice. European Journal of Neuroscience,
12: 4038-4046 (2000).
- C. Spielewoy, F. Gonon, C. Roubert, M. Jaber, M.G. Caron,
B.P. Roques, M. Hamon, C. Betancur, R. Maldonado, B. Giros.
Increased rewarding properties of morphine in dopamine-transporter
knockout mice. European Journal of Neuroscience, 12: 1827-1837
(2000).
- E. Tzavara, E. Valjent, C. Firmo, M. Mas, F. Beslot, N.
Defer, B.P. Roques, J. Hanoune, R. Maldonado. Cannabinoid
withdrawal is dependent upon PKA activation in the cerebellum.
European Journal of Neuroscience, 12: 1038-1046 (2000).
- E. Valjent, R. Maldonado. A behavioural model to reveal
place preference to delta9-tetrahydrocannabinol in mice.
Psychopharmacology, 147: 436-438 (2000).
- E. Valjent, J.C. Corvol, C. Pagès, M.J. Besson,
R. Maldonado, J. Caboche. Involvement of the extracellular
signal-regulated kinase cascade for cocaine-rewarding properties.
Journal of Neuroscience , 20: 8701-8709 (2000).
- O. Valverde, R. Maldonado, E. Valjent, A.M. Zimmer, A.
Zimmer. Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin
knockout mice. Journal of Neuroscience, 20: 9284-9289 (2000).
D.M.
Hutcheson, P. Sanchez-Blazquez, M. Rodriguez-Diaz, J. Garzon,
H. Schmidhammer, A. Borsodi, B.P. Roques, R. Maldonado.
Use of selective
opioid antagonists and antisense oligonucleotides to evaluate
the mechanisms involved on BUBU antinociception. European
Journal of Pharmacology, 383, pp:29-37. 1999.
R.
Maldonado, C. Smadja, C. Mazzuchelli, P. Sassone-Corsi.
Altered emotional
and Locomotor Responses in mice deficient in the transcription
factor CREM. Proceeding of the National Academy of Sciences
USA, 96, pp:14094-14099. 1999.
A.
Marki, K. Monory, F. Otvos, G. Toth, H. Schmidhammer, J.R.
Traynor, B.P. Roques, R. Maldonado, A. Borsodi. Mu
opioid receptor specific antagonist cyprodime: Characterisation
by in vitro radioligand and (35S)GTP?S binding assays.
European Journal of Pharmacology, 383, pp: 209-214. 1999.
- A.I. Pilyavskii, N.V. Bulgakova, R. Maldonado B.P: Roques,
V.A. Yakhnitsa. Effects of a delta opioid receptor agonist
and inhibitors of enkephalin catabolism on periaueductal
gray neurons in the rat midbrain: an in vitro study. Neurophysiology,
31, pp: 386-394. 1999.
J.A.
Blendy, R. Maldonado. Genetic
analysis of drug addiction: The role of cAMP response element
binding protein. Journal of Molecular Medicine, 76,
pp:104-110. 1998.
D.M.
Hutcheson, E.T. Tzavara, C. Smadja, E. Valjent, B.P. Roques,
J. Hanoune, R. Maldonado.
Behavioural and biochemical evidence for signs of abstinence
in mice chronically treated with Delta 9-tetrahydrocannabinol.
British Journal of Pharmacology, 125, pp:1567-1577.
A.S.
Kimes, R. Maldonado, E. Ambrosio, G.F. Koob, E.D. London.
Cerebral glucose metabolism
during opioid withdrawal following by methylnaloxonium injection
into the locus coeruleus. Brain Research, 814, pp:1-12.
1998.
H.
Matthes, C. Smadja, O. Valverde, J.L. Vonesch, A. Foutz,
E. Boudinot, M. Denavit-Saubié, L. Severini, L. Negri,
B.P. Roques, R. Maldonado, B.L. Kieffer. Activity
of the delta-opioid receptor is partially reduced, whereas
activity of the kappa-receptors is maintained in mice lacking
the mu-receptor. Journal of Neuroscience, 18, pp: 7285-7295.
1998.
A.
Ortega-Alvaro, A.J. Chover-González, R. Lai-Kuen,
J.A. Mico, J. Gibert-Rahola, M.C. Fournié-Zaluski,
B.P. Roques, R. Maldonado. Antinociception
produced by the peptidase inhibitor, RB 101, in rats with
adrenal medullary transplant into the spinal cord. European
Journal of Pharmacology , 356, pp:139-148. 1998.
F.
Simonin, O. Valverde, C. Smadja, S. Slowe, I. Kitchen, A.
Dierich, M. Le Meur, B.P. Roques, R. Maldonado, B. Kieffer.
Disruption of the kappa-opioid
receptor gene in mice enhances sensitivity to chemical visceral
pain, impairs pharmacological actions of the selective kappa
agonist U-50,488H and attenuates morphine withdrawal. EMBO
Journal, 17, pp:886-897. 1998.
- S.K. Sudakov, I.V. Liupina, O.F. Medvedeva, I.V. Tiurina,
R. Maldonado. Characteristics effects of mu-, delta-, and
kappa-opioid agonists and enkephalinase inhibitor RB 101
in rats of two inbred strains. Biull. Eksp. Biological Medicine,
125, pp: 551-554. 1998. In Russian.
P.
Tejedor-Real, J.A. Mico, C. Smadja, R. Maldonado, B.P. Roques,
J. Gibert-Rahola.
Involvement of delta-opioid receptors in the effects induced
by endogenous enkephalins on learned helplessness model.
European Journal of Pharmacology, 354, pp:1-7. 1998.
- O. Valverde, R. Maldonado, B.L. Kieffer. Recent findings
on mechanism of action of morphine. CNS Drugs, 10, pp:1-10.
1998.
R.
Maldonado. Participation
of noradrenergic pathways in the expression of opiate withdrawal:
Biochemical and pharmacological evidences. Neuroscience
Biovehavioural Review, 21, pp: 91-104. 1997.
R.
Maldonado, A. Saiardi, O. Valverde, T.A. Samad, B.P. Roques,
E. Borrelli. Absence
of opiate rewarding effects in mice lacking dopamine D2
receptors. Nature, 388, pp: 586-589. 1997.
F.
Noble, C. Smadja, O. Valverde, R. Maldonado, P. Coric, S.
Turcaud, M.C. Fournié-Zaluski, B.P. Roques. Pain-suppressive
effects on various nociceptive stimuli (thermal, chemical,
electrical and inflammatory) of the first orally active
enkephalin-metabolizing enzyme inhibitor RB 120. Pain,
73, pp: 383-391. 1997.
C.
Smadja, F. Ruiz, P. Coric, M.C. Fournié-Zaluski,
B.P. Roques, R. Maldonado. CCK-B
receptors in the limbic system modulate the antidepressant-like
effects induced by endogenous enkephalins. Psychopharmacology,
132, pp: 227-236. 1997.
O.
Valverde, C. Smadja, B.P. Roques, R. Maldonado. The
attenuation of morphine-conditioned place preference following
chronic mild stress is reversed by a CCK-B receptor antagonist.
Psychopharmacology, 131, pp:79-85. 1997.
R.
Maldonado, J.A. Blendy, E. Tzavara, P. Gass, B.P. Roques,
J. Hanoune, G. Schütz. Reduction
of morphine abstinence in mice with a mutation in the gene
encoding CREB. Science, 273, pp: 657-659. 1996.
H.W.D.
Matthes, R. Maldonado, F. Simonin, O. Valverde, S. Slowe,
I. Kitchen, K. Befort, A. Dierich, M. Le Meur, P. Dollé,
E. Tzavara, J. Hanoune, B.P. Roques, B.L. Kieffer. Loss
of morphine-induced analgesia, reward effect and withdrawal
symptoms in mice lacking the µ-opioid-receptor gene.
Nature, 383, pp: 759-760. 1996.
F.
Ruiz, M.C. Fournié-Zaluski, B.P. Roques, R. Maldonado.
Similar decrease in spontaneous
morphine abstinence by methadone and RB101, an inhibitor
or enkephalin catabolism. British Journal of Pharmacology,
119, pp:174-182. 1996.
O.
Valverde, M.C. Fournié-Zaluski, B.P. Roques, R. Maldonado.
The CCK-B antagonist
PD-134,308 facilitates rewarding actions induced by endogenous
enkephalins but does not induce place preference in rats.
Psychopharmacology,123, pp: 119-126. 1996.
O.
Valverde, M.C. Fournié-Zaluski, B.P. Roques, R. Maldonado.
Similar involvement
of several brain areas in the antinociception induced by
exogenous and endogenous opioids. European Journal of
Pharmacology, 312, pp: 15-25. 1996.
- O. Valverde, E. Tzavara, J. Hanoune, B.P. Roques, R. Maldonado.
Protein kinases in the rat nucleus accumbens are involved
in the aversive component of opiate withdrawal. European
Journal of Neuroscience, 8, pp: 2671-2678. 1996.
- R. Maldonado, O. Valverde, B. Ducos, A.G. Blommaert, M.C.
Fournié-Zaluski, B.P. Roques. Inhibition of morphine
withdrawal by the association of RB101 an inhibitor of enkephalin
catabolism, and the CCKB antagonist PD-134,308. British
Journal of Pharmacology, 114 (5), 1031-1039. 1995.
- C. Smadja, R. Maldonado, S. Turcaud, M.C. Fournié-Zaluski,
B.P. Roques. Opposite role of CCKA and CCKB receptors in
the modulation of endogenous enkephalins antidepressant-like
effects. Psychopharmacology, 120 (4), pp:400-408. 1995.
P.
Tejedor-Real, J. A. Micó, R. Maldonado, B. P. Roques,
J. Gibert-Rahola. Implication of endogenous opioid system
in the learned helplessness model of depression. Pharmacology,
Biochemistry and Behaviour, 52, pp:145-152. 1995. tejedor-real_et_al_1995.pdf
O.
Valverde, A. Blommaert, M.C. Fournié-Zaluski, B.P.
Roques, R. Maldonado. Weak
tolerance to the antinociceptive effect induced by the association
of a peptidase inhibitor and a CCKB receptor antagonist.
European Journal of Pharmacology, 286, pp: 79-93. 1995.
O.
Valverde, R. Maldonado, J.A. Mico, J. Gibert-Rahola. Study
of the mechanisms involved in behavioral changes induced
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