|
|
| |
 G.N.
Balerio, E. Aso, R. Maldonado. Role
of the cannabinoid system in the effects induced by nicotine
on anxiety-like behaviour in mice. Psychopharmacology,
184: 504–513 (2006).- J.
Brea, M. Castro, M. I. Loza, C. F. Masaguer, E. Raviña,
C. Dezi, M. Pastor, F. Sanz, A. Cabrero-Castel, B. Galán-Rodríguez,
E. Fernández-Espejo, R. Maldonado, P. Robledo. QF2004B,
a potential antipsychotic butyrophenone derivative with
similar pharmacological properties to clozapine. Neuropharmacology,
51:251-62 (2006).
- A.
Castañé, E. Célérier, M. Martín,
C. Ledent, M. Parmentier, R. Maldonado, O. Valverde. Development
and expresion of neuropathic pain in CB1 knockout mice.
Neuropharmacology, 50: 111-122 (2006).
- A.
Castañé, G. Soria, C. Ledent, R. Maldonado,
O. Valverde. Attenuation
of nicotine-induced rewarding effects in A2A knockout mice.
Neuropharmacology, 51:631-40 (2006).
- E.
Célérier, T. Ahdepil, H. Wikander, F. Berrendero,
F. Nyberg, R. Maldonado. Influence
of the anabolic-androgenic steroid nandrolone on cannabinoid
dependence. Neuropharmacology, 50(7):788-806 (2006).
- M.
Dierssen, M. Gratacòs, I. Sahún, M. Martín,
X. Gallego, A. Amador-Arjona, M. Martínez de Lagrán,
P. Murtra, E. Martí, M. A. Pujana, I. Ferrer, E.
Dalfó, C. Martínez-Cué, J. Flórez,
J. F. Torres-Peraza, J. Alberch, R. Maldonado, C. Fillat,
X. Estivill. Transgenic
mice overexpressing the full-length neurotrophin receptor
TrkC exhibit increased catecholaminergic neuron density
in specific brain areas and increased anxiety-like behavior
and panic reaction. Neurobiology of disease, In Press.
- L.
Galeote, B.L. Kieffer, R. Maldonado, F. Berrendero. Mu-opioid
receptors are involved in the tolerance to nicotine antinociception.
Journal of Neurochemistry, 97: 416–423 (2006).
- R.
Maldonado, O. Valverde, F. Berrendero. The
involvement of the endocannabinoid system in drug addiction.
Trends in Neuroscience, Invited review. 29:225-32 (2006).
- V.
Mendizábal, A. Zimmer, R. Maldonado. Involvement
of k/Dynorphin System in WIN 55,212-2 Self-Administration
in Mice. Neuropsychopharmacology, 31: 1957-66 (2006).
- X.
Nadal, Josep-Eladi Baños, B. L. Kieffer, R. Maldonado.
Neuropathic pain is enhanced in d-opioid receptor knockout
mice. European Journal of Neuroscience, 23: 830–834
(2006). Nadal et al_2006.pdf
- O.
Pol, P. Murtra, L. Caracuel, O. Valverde, M.M. Puig, R.
Maldonado. Expression
of opioid receptors and c-fos in CB1 knockout mice exposed
to neuropathic pain. Neuropharmacology, 50: 123-132
(2006).
- G.
Soria, A. Castañé, C. Ledent, M. Parmentier,
R. Maldonado, O. Valverde. The
lack of A2A adenosine receptors diminishes the reinforcing
efficacy of cocaine. Neuropsychopharmacology, 31:978-987
(2006). Soria et al 2006.pdf
- J.M.
Trigo, F. Panayi, G. Soria, R. Maldonado, P. Robledo. A
reliable model of intravenous MDMA self-administration in
naïve mice. Psychopharmacology, 184: 212–220,
(2006).
- G.N.
Balerio, E. Aso, R. Maldonado. Involvement
of the opioid system in the effects induced by nicotine
in anxiety-like behaviour in mice. Psychopharmacology,
181: 260-269 (2005).
- F.Berrendero,
V. Mendizábal, P. Robledo, L. Galeote, A. Bilkei-Gorzo,
A. Zimmer, R. Maldonado. Nicotine-induced
antinociception, rewarding effects and physical dependence
are mediated by preproenkephalin derivates. Journal
of Neuroscience, 25: 1103-1112 (2005).
- A.
Castañé, F. Berrendero, R. Maldonado. The
role of the cannabinoid system in nicotine addiction.
Pharmacology Biochemistry and Behavior, 81: 381-386 (2005).
- P.
Laurent, J.A. Becker, O. Valverde, C. Ledent, A. De , J.A.
Becker, O. Valverde, C. Ledent, A. De Kerchove d’Exaerde,
S.N. Schiffmann, R. Maldonado, G. Vassart, M. Parmentier.
The prolactin-releasing
peptide antagonizes the opioid system through its receptor
GPR10. Nature Neuroscience, 8: 1735-1741 (2005).
- G.
Soria, V. Mendizábal, C. Touriño, P. Robledo,
C. Ledent, M. Parmentier, R. Maldonado, O. Valverde. Lack
of CB1 receptor impairs cocaine self-administration.
Neuropsychopharmacology, 30: 1670-1680 (2005).
- L.
Urigüen, F. Berrendero, C. Ledent, R. Maldonado, J.
Manzanares. k- and
d-opioid receptor functional activities are increased in
the caudate putamen of cannabinoid CB1 receptor knockout
mice. European Journal of Neuroscience, 22: 2106–2110
(2005).
- G.N.
Balerio, E. Aso, F. Berrendero, P. Murtra, R. Maldonado.
Delta9-tetrahydrocannabinol
decreases somatic and motivational manifestations of nicotine
withdrawal in mice. European Journal of Neuroscience,
20: 2737-2748 (2004).
- A. Castañé, R. Maldonado, O. Valverde. Role
of different brain structures in the behavioural expression
of WIN 55,212-2 withdrawal in mice. British Journal of Pharmacology,
142: 1309-1317 (2004).
- E.
Célérier, G. Simonnet, R. Maldonado. Prevention
of fentanyl-induced delayed pronociceptive effects in mice
lacking the protein kinase Cgamma gene. Neuropharmacology,
46: 264-272 (2004).
- J.A.
García-Sevilla, M. Ferrer-Alcón, M. Martín,
B.L. Kieffer, R. Maldonado. Neurofilament
proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid
receptor gene knockout mice: effects of chronic morphine
administration.
Neuropharmacology, 46: 519-530 (2004).
- P. Robledo, G. Balerio, F. Barrendero, R. Maldonado. Study
of the behavioral responses related to the potential addictive
properties of MDMA in mice. Naunyn-Schmiedeberg’s Archives
of Pharmacology, 369: 338-349 (2004).
- P.
Robledo, V. Mendizabal, J. Ortuño, R. de la Torre,
B.L. Kieffer, R. Maldonado. The
rewarding properties of MDMA are preserved in mice lacking
mu-opioid receptors. European Journal of Neuroscience,
20: 853-858 (2004).
- G.
Soria, A. Castañé, F. Berrendero, C. Ledent,
M. Parmentier, R. Maldonado, O. Valverde. Adenosine
A2A receptors are involved in physical dependence and place
conditioning induced by THC. European Journal of Neuroscience,
20: 2203-2213 (2004).
- O.
Valverde, T. Mantamadiotis, M. Torrecilla, L. Ugedo, J.
Pineda, S. Bleckmann, P. Gass, O. Kretz, J.M. Mitchell,
G. Schütz, R. Maldonado. Modulation
of anxiety-like behavior and morphine dependence in CREB-deficient
mice. Neuropsychopharmacology, 29: 1122-1133 (2004).
- O. Valverde, P. Robledo, R. Maldonado. Involvement of
the endogenous opioid system in cannabinoid responses. Current
Medicinal Chemistry-CNS Agents, 4: 183-193 (2004).
- F.
Berrendero, A. Castañé, C. Ledent, M. Parmentier,
R. Maldonado, O. Valverde. Increase
of morphine withdrawal in mice lacking A2a receptors and
no changes in CB1/A2a double knockout mice. European
Journal of Neuroscience, 17: 315-324 (2003).
- F.
Berrendero, V. Mendizábal, P. Murtra, B.L. Kieffer,
R. Maldonado. Cannabinoid
receptor and WIN 55 212-2-stimulated ([35S]-GTP?S binding
in the brain of mu-, delta- and kappa-opioid receptor knockout
mice. European Journal of Neuroscience, 18: 2197-2202
(2003).
- A.
Castañé, P. Robledo, A. Matifas, B.L. Kieffer,
R. Maldonado. Cannabinoid
withdrawal syndrome is reduced in double mu and delta opioid
receptor knockout mice. European Journal of Neuroscience,
17: 155- 159 (2003).
- E. Célérier, F.M. Yadzi, A. Castañé,
S. Ghozland, F. Nyberg, R. Maldonado. Effects of nandrolone
on acute morphine responses, tolerance and dependence in
mice. European Journal of Pharmacology, 465: 69-81 (2003).
- S. Le Guen, M. Mas Nieto, C. Canestrelli, H. Chen, M.C.
Fournié-Zaluski, A. Cupo, R. Maldonado, B.P. Roques,
F. Noble. Pain management by a new series of dual inhibitors
of enkephalin degrading enzymes: long lasting antinociceptive
properties and potentiation by CCK2 antagonist or methadone.
Pain, 104: 139-148 (2003).
- R. Maldonado. The neurobiology of addiction. Journal of
Neural Transmission, 66: 1-14 (2003).
- R. Maldonado, O. Valverde. Participation of the opioid
system in cannabinoid-induced antinociception and emotional-like
responses. European Neuropsychopharmacology, 13: 401-410
(2003).
- M. Martín, A. Matifas, R. Maldonado, B.L. Kieffer.
Acute antinoceptive responses in single and combinatorial
opioid receptor knockout mice: distinct mu, delta and kappa
tones. European Journal of Neuroscience, 17: 701-708 (2003).
- M. Martín, C. Otto, M.T. Santamarta, M. Torrecilla,
J. Pineda, G. Schütz, R. Maldonado. Morphine withdrawal
is modified in pituitary adenylate cyclase-activating polipeptide
type I-receptor-deficient mice. Molecular Brain Research,
110: 109-118 (2003).
- F.
Berrendero, B.L. Kieffer, R. Maldonado. Attenuation
of nicotine-induced antinociception, rewarding effects,
and dependence in mu-opioid receptor knock-out mice.
Journal of Neuroscience, 22: 10935-10940 (2002).
- F. Berrendero, R. Maldonado. Involvement of the opioid
system in the anxiolytic-like effects induced by Delta(9)-tetrahydrocannabinol.
Psychopharmacology, 163: 111-117 (2002).
- A.
Castañé, E. Valjent, C. Ledent, M. Parmentier,
R. Maldonado, O. Valverde. Lack
of CB1 cannabinoid receptors modifies nicotine behavioural
responses, but not nicotine abstinence. Neuropharmacology,
43: 857-867 (2002).
- S. Ghozland, F. Aguado, J.F. Espinosa-Parrilla, E. Soriano,
R. Maldonado. Spontaneous network activity of cerebellar
granule neurons: impairment by in vivo chronic cannabinoid
administration. European Journal of Neuroscience, 16: 641-651
(2002).
- S.
Ghozland, H.W.D. Matthews, F. Simonin, D. Filliol, B.L.
Kieffer, R. Maldonado. Motivocional
effects of cannabinoids are mediated by mu-opioid and kappa-opioid
receptors. Journal of Neuroscience, 22: 1146-1154 (2002).
- M. Maccarrone, O. Valverde, M.L. Barbaccia, A. Castañé,
R. Maldonado, C. Ledent, M. Parmentier, A. Finazzi-Agro.
Age-related changes of anandamide metabolism in CB1 cannabinoid
receptor knockout mice: correlation with behaviour. European
Journal of Neuroscience, 15: 1178-1186 (2002).
- R. Maldonado. Study of cannabinoid dependence in animals.
Pharmacology & Therapeutics, 95: 153-164 (2002).
- R.
Maldonado, F. Rodríguez de Fonseca. Cannabinoid
addiction: behavioral models and neural correlates.
Journal of Neuroscience, 22: 3326-3331 (2002).
- M. Martin, C. Ledent, M. Parmentier, R. Maldonado, O.
Valverde. Involvement of CB-1 cannabinoid receptors in emotional
behaviour. Psycochopharmacology, 159: 379-387 (2002).
- C.
Mazzucchelli, C. Vantaggiato, A. Ciamei, S. Fasano, P. Pakhotin,
W. Krezel, H. Welzl, D.P. Wolfer, G. Pages, O. Valverde,
A. Marowsky, A. Porrazzo, P.C. Orban, R. Maldonado, M.U.
Ehrengruber, V. Cestari, H.P. Lipp, P.F. Chapman, J. Pouysségur,
R. Brambilla. Knockout
of ERK1 MAP kinase enhances synaptic plasticity in the striatum
and facilitates striatal-mediated learning and memory.
Neuron, 34: 807-820 (2002).
- E. Valjent, J. Mitchell, M.J. Besson, J. Caboche, R. Maldonado.
Behavioural and biochemical interactions between ?9-tetrahidrocannabinol
and nicotine. British Journal of Pharmacology, 135: 564-578
(2002).
- D. Hutcheson, H.W.D. Matthes, E. Valjent, P. Sanchez-Blazquez,
M. Rodriguez-Diaz, J. Garzon, B.L. Kieffer, R. Maldonado.
Lack of dependence and rewarding effects of deltorphin II
in mu-opioid receptor-deficient mice. European Journal of
Neuroscience, 13: 153-161 (2001).
- R. Maldonado, C. Severini, H.W.D. Matthes, B.L. Kieffer,
P. Melchiorri, L. Negri
Activity of mu- and delta-opioid agonists in vas deferens
from mice deficient in MOR gene. British Journal of Pharmacology,
132: 1485-1492 (2001).
- M.
Navarro, M.R.A. Carrera, W. Fratta, O. Valverde, G. Cossu,
L. Fattore, J.A. Chowen, R. Gómez, I. del Arco, M.A.
Villanúa, R. Maldonado, G.F. Koob, F. Rodríguez
de Fonseca. Functional
Interaction between opioid and cannabinoid receptors in
drug self-administration. Journal of Neuroscience, 21:
5344-5350 (2001).
- C.
Otto, Y. Kovalchuk, D. Wolfer, P. Gass. M. Martin, W. Zuschratter,
H.J. Gröne, C. Kellendonk, F. Tronche, R. Maldonado,
H. P. Lipp, A. Konnerth, G. Schütz. Impairment
of mossy fiber long-term potentiation and associative learning
in pituitary adenylate cyclase activating polypeptide type
I receptor-deficient mice. Journal of Neuroscience,
21: 5520-5527 (2001).
- C. Otto, M. Martin, D. P. Wolfer, H. P. Lipp, R. Maldonado,
G. Schütz. Altered emotional behaviour in PACAP-type-I-receptor-deficient
mice. Molecular Brain Research, 92: 78-84 (2001).
- E. Valjent, C. Pages, M. Rogard, M. J. Besson , R. Maldonado,
J. Caboche. Delta-9-tetrahydrocannabinol–induced MAPK-/ERK
and Elk-1 activation in vivo depends on dopaminergic transmission.
European Journal of Neuroscience, 14: 342-352 (2001).
- A.
Zimmer, E. Valjent, M. König, A. M. Zimmer, P. Robledo,
H. Hahn, O. Valverde, R. Maldonado. Absense
of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient
mice. Journal of Neuroscience, 21: 9499-9505 (2001).
- D. Filliol, S. Ghozland, J. Chluba, M. Martin, H.W.D.
Matthes, F. Simonin, K. Befort, C. Gavériaux-Ruff,
A. Dierich, M. LeMeur, O. Valverde, R. Maldonado, B.L. Kieffer.
Mice deficient for delta- and mu-opiod receptors exhibit
opposing alterations of emotional responses. Nature Genetics,
25: 195-200 (2000).
- D. Hutcheson, F. Subhan, D.M. Pache, R. Maldonado, M.C.
Fournié-Zaluski, B.P. Roques, R.D.E. Sewell. Analgesic
doses of the enkephalin degrading enzyme inhibitor RB 120
do not have discriminative stimulus properties. European
Journal of Pharmacology, 401: 197-204 (2000).
- M. Martin, C. Ledent, M. Parmentier, R. Maldonado, O.
Valverde. Cocaine, but not morphine, induces conditioned
place preference and sensitization to locomotor responses
in CB1 knockout mice. European Journal of Neuroscience,
12: 4038-4046 (2000).
- C. Spielewoy, F. Gonon, C. Roubert, M. Jaber, M.G. Caron,
B.P. Roques, M. Hamon, C. Betancur, R. Maldonado, B. Giros.
Increased rewarding properties of morphine in dopamine-transporter
knockout mice. European Journal of Neuroscience, 12: 1827-1837
(2000).
- E. Tzavara, E. Valjent, C. Firmo, M. Mas, F. Beslot, N.
Defer, B.P. Roques, J. Hanoune, R. Maldonado. Cannabinoid
withdrawal is dependent upon PKA activation in the cerebellum.
European Journal of Neuroscience, 12: 1038-1046 (2000).
- E. Valjent, R. Maldonado. A behavioural model to reveal
place preference to delta9-tetrahydrocannabinol in mice.
Psychopharmacology, 147: 436-438 (2000).
- E. Valjent, J.C. Corvol, C. Pagès, M.J. Besson,
R. Maldonado, J. Caboche. Involvement of the extracellular
signal-regulated kinase cascade for cocaine-rewarding properties.
Journal of Neuroscience , 20: 8701-8709 (2000).
- O. Valverde, R. Maldonado, E. Valjent, A.M. Zimmer, A.
Zimmer. Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin
knockout mice. Journal of Neuroscience, 20: 9284-9289 (2000).
- D.M.
Hutcheson, P. Sanchez-Blazquez, M. Rodriguez-Diaz, J. Garzon,
H. Schmidhammer, A. Borsodi, B.P. Roques, R. Maldonado.
Use of selective
opioid antagonists and antisense oligonucleotides to evaluate
the mechanisms involved on BUBU antinociception. European
Journal of Pharmacology, 383, pp:29-37. 1999.
- R.
Maldonado, C. Smadja, C. Mazzuchelli, P. Sassone-Corsi.
Altered emotional
and Locomotor Responses in mice deficient in the transcription
factor CREM. Proceeding of the National Academy of Sciences
USA, 96, pp:14094-14099. 1999.
- A.
Marki, K. Monory, F. Otvos, G. Toth, H. Schmidhammer, J.R.
Traynor, B.P. Roques, R. Maldonado, A. Borsodi. Mu
opioid receptor specific antagonist cyprodime: Characterisation
by in vitro radioligand and (35S)GTP?S binding assays.
European Journal of Pharmacology, 383, pp: 209-214. 1999.
- A.I. Pilyavskii, N.V. Bulgakova, R. Maldonado B.P: Roques,
V.A. Yakhnitsa. Effects of a delta opioid receptor agonist
and inhibitors of enkephalin catabolism on periaueductal
gray neurons in the rat midbrain: an in vitro study. Neurophysiology,
31, pp: 386-394. 1999.
- J.A.
Blendy, R. Maldonado. Genetic
analysis of drug addiction: The role of cAMP response element
binding protein. Journal of Molecular Medicine, 76,
pp:104-110. 1998.
- D.M.
Hutcheson, E.T. Tzavara, C. Smadja, E. Valjent, B.P. Roques,
J. Hanoune, R. Maldonado.
Behavioural and biochemical evidence for signs of abstinence
in mice chronically treated with Delta 9-tetrahydrocannabinol.
British Journal of Pharmacology, 125, pp:1567-1577.
- A.S.
Kimes, R. Maldonado, E. Ambrosio, G.F. Koob, E.D. London.
Cerebral glucose metabolism
during opioid withdrawal following by methylnaloxonium injection
into the locus coeruleus. Brain Research, 814, pp:1-12.
1998.
- H.
Matthes, C. Smadja, O. Valverde, J.L. Vonesch, A. Foutz,
E. Boudinot, M. Denavit-Saubié, L. Severini, L. Negri,
B.P. Roques, R. Maldonado, B.L. Kieffer. Activity
of the delta-opioid receptor is partially reduced, whereas
activity of the kappa-receptors is maintained in mice lacking
the mu-receptor. Journal of Neuroscience, 18, pp: 7285-7295.
1998.
- A.
Ortega-Alvaro, A.J. Chover-González, R. Lai-Kuen,
J.A. Mico, J. Gibert-Rahola, M.C. Fournié-Zaluski,
B.P. Roques, R. Maldonado. Antinociception
produced by the peptidase inhibitor, RB 101, in rats with
adrenal medullary transplant into the spinal cord. European
Journal of Pharmacology , 356, pp:139-148. 1998.
- F.
Simonin, O. Valverde, C. Smadja, S. Slowe, I. Kitchen, A.
Dierich, M. Le Meur, B.P. Roques, R. Maldonado, B. Kieffer.
Disruption of the kappa-opioid
receptor gene in mice enhances sensitivity to chemical visceral
pain, impairs pharmacological actions of the selective kappa
agonist U-50,488H and attenuates morphine withdrawal. EMBO
Journal, 17, pp:886-897. 1998.
- S.K. Sudakov, I.V. Liupina, O.F. Medvedeva, I.V. Tiurina,
R. Maldonado. Characteristics effects of mu-, delta-, and
kappa-opioid agonists and enkephalinase inhibitor RB 101
in rats of two inbred strains. Biull. Eksp. Biological Medicine,
125, pp: 551-554. 1998. In Russian.
- P.
Tejedor-Real, J.A. Mico, C. Smadja, R. Maldonado, B.P. Roques,
J. Gibert-Rahola.
Involvement of delta-opioid receptors in the effects induced
by endogenous enkephalins on learned helplessness model.
European Journal of Pharmacology, 354, pp:1-7. 1998.
- O. Valverde, R. Maldonado, B.L. Kieffer. Recent findings
on mechanism of action of morphine. CNS Drugs, 10, pp:1-10.
1998.
- R.
Maldonado. Participation
of noradrenergic pathways in the expression of opiate withdrawal:
Biochemical and pharmacological evidences. Neuroscience
Biovehavioural Review, 21, pp: 91-104. 1997.
- R.
Maldonado, A. Saiardi, O. Valverde, T.A. Samad, B.P. Roques,
E. Borrelli. Absence
of opiate rewarding effects in mice lacking dopamine D2
receptors. Nature, 388, pp: 586-589. 1997.
- F.
Noble, C. Smadja, O. Valverde, R. Maldonado, P. Coric, S.
Turcaud, M.C. Fournié-Zaluski, B.P. Roques. Pain-suppressive
effects on various nociceptive stimuli (thermal, chemical,
electrical and inflammatory) of the first orally active
enkephalin-metabolizing enzyme inhibitor RB 120. Pain,
73, pp: 383-391. 1997.
- C.
Smadja, F. Ruiz, P. Coric, M.C. Fournié-Zaluski,
B.P. Roques, R. Maldonado. CCK-B
receptors in the limbic system modulate the antidepressant-like
effects induced by endogenous enkephalins. Psychopharmacology,
132, pp: 227-236. 1997.
- O.
Valverde, C. Smadja, B.P. Roques, R. Maldonado. The
attenuation of morphine-conditioned place preference following
chronic mild stress is reversed by a CCK-B receptor antagonist.
Psychopharmacology, 131, pp:79-85. 1997.
- R.
Maldonado, J.A. Blendy, E. Tzavara, P. Gass, B.P. Roques,
J. Hanoune, G. Schütz. Reduction
of morphine abstinence in mice with a mutation in the gene
encoding CREB. Science, 273, pp: 657-659. 1996.
- H.W.D.
Matthes, R. Maldonado, F. Simonin, O. Valverde, S. Slowe,
I. Kitchen, K. Befort, A. Dierich, M. Le Meur, P. Dollé,
E. Tzavara, J. Hanoune, B.P. Roques, B.L. Kieffer. Loss
of morphine-induced analgesia, reward effect and withdrawal
symptoms in mice lacking the µ-opioid-receptor gene.
Nature, 383, pp: 759-760. 1996.
- F.
Ruiz, M.C. Fournié-Zaluski, B.P. Roques, R. Maldonado.
Similar decrease in spontaneous
morphine abstinence by methadone and RB101, an inhibitor
or enkephalin catabolism. British Journal of Pharmacology,
119, pp:174-182. 1996.
- O.
Valverde, M.C. Fournié-Zaluski, B.P. Roques, R. Maldonado.
The CCK-B antagonist
PD-134,308 facilitates rewarding actions induced by endogenous
enkephalins but does not induce place preference in rats.
Psychopharmacology,123, pp: 119-126. 1996.
- O.
Valverde, M.C. Fournié-Zaluski, B.P. Roques, R. Maldonado.
Similar involvement
of several brain areas in the antinociception induced by
exogenous and endogenous opioids. European Journal of
Pharmacology, 312, pp: 15-25. 1996.
- O. Valverde, E. Tzavara, J. Hanoune, B.P. Roques, R. Maldonado.
Protein kinases in the rat nucleus accumbens are involved
in the aversive component of opiate withdrawal. European
Journal of Neuroscience, 8, pp: 2671-2678. 1996.
- R. Maldonado, O. Valverde, B. Ducos, A.G. Blommaert, M.C.
Fournié-Zaluski, B.P. Roques. Inhibition of morphine
withdrawal by the association of RB101 an inhibitor of enkephalin
catabolism, and the CCKB antagonist PD-134,308. British
Journal of Pharmacology, 114 (5), 1031-1039. 1995.
- C. Smadja, R. Maldonado, S. Turcaud, M.C. Fournié-Zaluski,
B.P. Roques. Opposite role of CCKA and CCKB receptors in
the modulation of endogenous enkephalins antidepressant-like
effects. Psychopharmacology, 120 (4), pp:400-408. 1995.
- P.
Tejedor-Real, J. A. Micó, R. Maldonado, B. P. Roques,
J. Gibert-Rahola. Implication of endogenous opioid system
in the learned helplessness model of depression. Pharmacology,
Biochemistry and Behaviour, 52, pp:145-152. 1995. tejedor-
real_et_al_1995.pdf
- O.
Valverde, A. Blommaert, M.C. Fournié-Zaluski, B.P.
Roques, R. Maldonado. Weak
tolerance to the antinociceptive effect induced by the association
of a peptidase inhibitor and a CCKB receptor antagonist.
European Journal of Pharmacology, 286, pp: 79-93. 1995.
- O.
Valverde, R. Maldonado, J.A. Mico, J. Gibert-Rahola. Study
of the mechanisms involved in behavioral changes induced
by flunitrazepam in morphine withdrawal. Progress in
Neuropsychopharmacology & Biological Psyquiatry, 19,
pp: 973-991. 1995.
- B. Vincent, V. Dive, A. Yiotakis, C. Smadja, R. Maldonado,
J.P. Vincent, F. Checler. Phosphorus-containing peptides
as mixed inhibitors of endopeptidase 3.4.24.15 and 3.4.24.16
: Effect on neurotensin degradation in vitro and in vivo.
British Journal of Pharmacology, 115 (6), pp: 1053-1063.
1995.
- R. Maldonado, O. Valverde, S. Turcaud, M.C. Fournié-Zaluski,
B.P. Roques. Antinociceptive response induced by mixed inhibitors
of the enkephalin catabolism in peripheral inflammation.
Pain, 58 (1), pp:77- 83. 1994.
- O. Valverde, R. Maldonado, M.C. Fournié-Zaluski,
B.P. Roques. Cholecystokinin B antagonists strongly potentiate
antinociception mediated by endogenous enkephalins. Journal
of Pharmacology and Experimental Therapeutics, 270 (1),
pp: 77-88. 1994.
- P. Tejedor-Real, J.A. Mico, R. Maldonado, B.P. Roques,
J. Gibert-Rahola. Effects of mixed (RB 38 A) and selective
(RB 38 B) inhibitors of enkephalin degrading enzymes on
a model of depression in the rat. Biological Psychiatry,
34 (1-2), pp: 100-107. 1993.
- M.C.
Fournié-Zaluski, P. Coric, S. Turcaud, E. Lucas,
F. Noble, R. Maldonado, B. P. Roques. "Mixed
inhibitor-Prodrug" as a new approach toward systemically
active inhibitors of enkephalin-degrading enzymes. Journal
of Medicinal Chemistry, 35 (26), pp: 2473-2481. 1992.
- G.F. Koob, R. Maldonado, L. Stinus. Neural substrates
of opiate withdrawal. Trends in Neuroscience, 15, pp:186-191.
1992.
- R. Maldonado, S. Negus, G.F. Koob. Precipitation of morphine
withdrawal syndrome in rats by administration of mu-, delta-
and kappa- selective opioid antagonists. Neuropharmacology,
31 (12), pp: 1231-1241. 1992.
- R. Maldonado, L., Stinus, L. Gold, G.F. Koob. Role of
different brain structures in the expression of the physical
morphine withdrawal syndrome. Journal of Pharmacology and
Experimental Therapeutics, 261, pp: 669-677. 1992.
- R. Maldonado, J.A. Micó, O. Valverde, M.C. Saavedra,
I. Leonsegui, J. Gibert-Rahola.
Influence of differents benzodiazepines on experimental
morphine abstinence syndrome. Psychopharmacology, 105, pp:
197-203. 1991.
- R. Maldonado, V. Daugé, J. Feger, B.P. Roques.
Chronic blockade of D2 but not D1 dopamine receptors facilitates
behavioural responses to endogenous enkephalins, protected
by kelatorphan, administered in the accumbens in rats. Neuropharmacology,
29 (3), pp: 215-223. 1990
|
|
|
|
|
